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目的:研究非小细胞肺癌P27基因表达与临床病理指标的关系及判断患者预后的价值。方法:应用免疫组化技术检测10例正常肺组织和56例非小细胞肺癌中P27基因的表达。结果:非小细胞肺癌P27蛋白表达阳性率为39%,而正常组织为80%。P27蛋白表达与肿瘤组织分化程度相关(tau_b=0.264,P<0.05)。P27阴性者预后较差(χ2=4.13,P<0.05)。结论:从蛋白水平揭示P27基因表达与非小细胞肺癌的分化程度相关,P27蛋白的表达与性别、年龄、吸烟指数、原发灶大小、病理类型、临床分期以及淋巴结转移有关,并有望成为判断非小细胞肺癌患者预后的参考指标之一。
Objective: To study the relationship between P27 gene expression and clinicopathological parameters in non-small cell lung cancer (NSCLC) and the value of prognosis in patients with non-small cell lung cancer. Methods: The expression of P27 gene in 10 normal lung tissues and 56 non-small cell lung cancer tissues was detected by immunohistochemistry. Results: The positive rate of P27 protein expression in non-small cell lung cancer was 39% compared with 80% in normal tissues. The expression of P27 protein correlated with tumor differentiation (tau_b = 0.264, P <0.05). P27 negative prognosis is poor (χ2 = 4.13, P <0.05). Conclusion: The expression of P27 protein is correlated with the differentiation degree of non-small cell lung cancer from the protein level. The expression of P27 protein is related to gender, age, smoking index, size of primary tumor, pathological type, clinical stage and lymph node metastasis, and is expected to become a judgment Prognosis of non-small cell lung cancer patients one of the indicators.