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目的观察马来酸桂哌齐特注射液对颅脑损伤后脑梗死的防治疗效。方法200例急性中重度颅脑损伤患者随机分为对照组和用药组,分析对比两组血液流变学、TCD(经颅多普勒检查)和GOS预后评分结果。结果治疗后应用马来酸桂哌齐特组的血液流变学各项指标均低于对照组(P<0.05)。TCD检测显示用药组的脑血流速度与对照组相比明显减慢(P<0.05),血管痉挛明显缓解,GOS预后评分显示用药组好于对照组。结论急性颅脑损伤早期应用马来酸桂哌齐特可有效缓解脑血管痉挛,增加病变区脑血流,改善微循环,防治外伤性脑梗死,改善预后。
Objective To observe the effect of cinepazide maleate injection on cerebral infarction after craniocerebral injury. Methods 200 patients with acute moderate-severe traumatic brain injury were randomly divided into control group and treatment group. The results of hemorheology, TCD (transcranial Doppler examination) and GOS prognosis were compared between the two groups. Results All indexes of hemorheology after treatment with cinepazide maleate were lower than those of the control group (P <0.05). TCD showed that the cerebral blood flow velocity of the treatment group was significantly slower than that of the control group (P <0.05), and vasospasm was significantly relieved. The GOS prognosis score showed that the medication group was better than the control group. Conclusion The application of cinepazide maleate early in acute craniocerebral injury can effectively relieve cerebral vasospasm, increase cerebral blood flow, improve microcirculation, prevent and treat traumatic cerebral infarction and improve prognosis.