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目的观察比较几种不同方法治疗新生儿缺氧缺血性心肌损害的疗效。方法将74例新生儿缺氧缺血性心肌损害的患儿随机分为治疗组A、B两组各25例,对照组24例。各组均给予常规治疗,在此基础上,治疗A组给予静脉滴注磷酸肌酸钠,治疗B组给予静脉滴注1,6-二磷酸果糖,观察各组患儿治疗前、治疗第7、第10天后症状、体征以及心电图、心肌酶谱的变化。结果治疗A、B组总有效率为92.0%,明显高于对照组的70.8%,治疗组与对照组治疗后心肌酶谱比较差异有统计学意义(P<0.05)。结论磷酸肌酸钠、1,6-二磷酸果糖治疗新生儿缺氧缺血性心肌损害均有显著疗效,未见不良反应。磷酸肌酸钠较1,6-二磷酸果糖疗效更快,可相对缩短住院周期。
Objective To observe and compare the curative effects of several different methods on neonatal hypoxic-ischemic myocardial damage. Methods Totally 74 neonates with hypoxic-ischemic myocardial damage were randomly divided into treatment group A and group B (25 cases) and control group (24 cases). Each group were given conventional treatment, on this basis, the treatment group A was given intravenous infusion of sodium creatine phosphate, and the treatment group B was given intravenous drip 1,6 - diphosphate fructose, observed in each group of children before treatment, treatment 7 , The first 10 days after the symptoms, signs and ECG, myocardial enzymes changes. Results The total effective rate of group A and B was 92.0%, which was significantly higher than that of control group (70.8%). There was significant difference in myocardial enzymes between treatment group and control group after treatment (P <0.05). Conclusion Both sodium creatine phosphate and fructose-1,6-diphosphate have a significant therapeutic effect on neonatal hypoxic-ischemic myocardium injury with no adverse reactions. Sodium creatine phosphate than fructose-1,6-diphosphate faster, can be relatively shorten the hospital cycle.