选取乙型肝炎后肝硬化失代偿期患者３０例，正常成人献血者２８例，对其血浆内毒素、肿瘤坏死因子α（ＴＮＦα）、内皮素１（ＥＴ１）水平进行检测。结果表明，肝硬化失代偿期患者三者的水平明显高于正常对照组，三者水平呈正相关，并随肝功减退而升高，提示三者与肝硬化失代偿关系密切 Thirty patients with decompensated liver cirrhosis and 28 normal blood donors were enrolled in this study. The levels of plasma endotoxin, tumor necrosis factor-α (TNFα) and endothelin1 (ET1) Detection. The results showed that patients with decompensated cirrhosis of the three levels was significantly higher than the normal control group, the three levels were positively correlated, and increased with the decline of liver function, suggesting that the three were closely related with decompensation of liver cirrhosis