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目的:比较不同剂量甘露醇对老年急性大面积脑梗死患者的疗效及安全性。方法:选取2014年12月—2015年12月间收治的急性大面积脑梗死患者130例,采用随机分组法将其分为对照组65例和观察组65例;对照组患者给予大剂量(250 m L)20%甘露醇治疗;观察组患者给予小剂量甘露醇治疗,比较两组患者用药后的总有效率和并发症的发生率。结果:观察组患者用药后的总有效率为64.62%高于对照组为58.46%(P<0.05);观察组患者用药后并发症(电解质紊乱、心衰、肾功能异常、肝功能异常)等发生率低于对照组(P<0.05)。结论:采用小剂量甘露醇治疗老年急性大面积脑梗死患者不仅能够确保其临床疗效,安全性高,可有效改善肝肾功能。
Objective: To compare the efficacy and safety of different doses of mannitol in elderly patients with acute large area cerebral infarction. Methods: A total of 130 patients with acute large area cerebral infarction who were admitted from December 2014 to December 2015 were randomly divided into control group (n = 65) and observation group (n = 65). Patients in the control group were given high dose m L) 20% mannitol. Patients in the observation group were treated with low-dose mannitol. The total effective rate and the complication rate were compared between the two groups. Results: The total effective rate in the observation group was 64.62%, which was significantly higher than that in the control group (58.46%, P <0.05). The complication (electrolyte disturbance, heart failure, renal dysfunction, liver dysfunction) The incidence was lower than that of the control group (P <0.05). Conclusion: The use of small doses of mannitol in elderly patients with acute large area cerebral infarction can not only ensure its clinical efficacy, safety, and can effectively improve liver and kidney function.