常用他汀类药物(如辛伐他汀、普伐他汀、匹伐他汀等)的说明书推荐服药时间为晚饭后或睡前。因为他汀类药物的化学结构与胆固醇的生物合成酶相似,能有效抑制体内胆固醇的生物合成。肝脏合成胆固醇有一定的昼夜规律,其合成高峰在晚间。因此,晚饭后或睡前服药效果更好。而对于单纯的甘油三酯升高患者来说,晨起服用他汀类药物获得的疗效要优于晚间给药,这可能与白天的血清甘油三酯水平等因素有 The usual instructions for statins (such as simvastatin, pravastatin, pitavastatin, etc.) recommend taking medication after dinner or before going to bed. Because the chemical structure of statins and cholesterol biosynthesis enzymes similar, can effectively inhibit the body’s cholesterol biosynthesis. Liver synthesis of cholesterol has a certain day and night law, the peak of its synthesis in the evening. Therefore, after dinner or bedtime medication better. For patients with elevated triglycerides, morning to start taking statins to obtain better efficacy than evening administration, which may be related to the level of serum triglyceride during the day and other factors