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目的分析急性心肌梗死(AMI)患者血清中心肌肌钙蛋白I(CTnI)的含量变化,并应用受试者工作特征曲线(ROC曲线)分析CTnI在AMI诊断中的价值。方法采用微粒子酶免疫法(MEIA法)分别测定患者组(包括AMI 组和非AMI组)和健康对照组血清CTnI,并用ROC曲线进行分析。结果AMI组血清CTnI明显高于非AMI组和健康对照组(P<0.01),非AMI组高于健康对照组(P<0.05)。CTnI单侧99%参考范围上限≤0.04μg/L,距离ROC曲线左上角最近的点为0.38μg/L,诊断敏感性为94.1%,特异性为95.5%。结论CTnI定量分析在AMI诊断中有较高的临床应用价值。CTnI浓度0.38μg/L可作为诊断AMI的参考上限。
Objective To analyze the changes of serum cardiac troponin I (CTnI) in patients with acute myocardial infarction (AMI) and to evaluate the value of CTnI in the diagnosis of AMI by using receiver operating characteristic curve (ROC curve). Methods Serum CTnI of patients (including AMI group and non-AMI group) and healthy control group were determined by MEIA method and analyzed by ROC curve. Results Serum CTnI in AMI group was significantly higher than that in non-AMI group and healthy control group (P <0.01), but not in AMI group (P <0.05). The upper limit of 99% of unilateral reference range of CTnI ≤0.04μg / L, the nearest point to the upper left corner of ROC curve was 0.38μg / L, the diagnostic sensitivity was 94.1% and the specificity was 95.5%. Conclusion Quantitative analysis of CTnI in the diagnosis of AMI has a high clinical value. CTnI concentration of 0.38μg / L can be used as a reference for the diagnosis of AMI ceiling.