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支气管粘膜上颗粒细胞和单个核细胞(包括T 淋巴细胞和单核细胞)浸润是哮喘的发病特征,中性白细胞参与引起的哮喘气道高反应性业已证实,然而单个核细胞(Mononuclear cells)通过何种环节介导细胞间相互作用,尤其中性白细胞的致炎过程,尚不清楚.作者对急性严重哮喘、轻型哮喘及慢性阻塞性肺疾病患者和正常人外周血单个核细胞(PBMC)进行培养,测定各自培养上清液的中性白细胞趋化因子活性(NCA).结果发现,急性严重哮喘患者组NCA 较其他三组明显增高(P<0.01);急性严重
Infiltration of granulosa cells and mononuclear cells (including T lymphocytes and monocytes) on the bronchial mucosa is a characteristic of asthma, and airway hyperresponsiveness to asthma caused by neutrophil involvement has been demonstrated. However, mononuclear cells It is unclear which link mediates the cell-cell interaction, especially the neutrophilic pro-inflammatory process. The authors investigated whether peripheral blood mononuclear cells (PBMC) from patients with acute severe asthma, light asthma, chronic obstructive pulmonary disease and normal persons (NCA) in each culture supernatant were measured.The results showed that the NCA of patients with acute severe asthma was significantly higher than that of the other three groups (P <0.01)