直接或间接作用于中枢神经系统的药物常被作为一种工具,以探讨中枢机能与生物化学之间的相互关系。已经证明乙酰胆碱(Ach)是周围胆碱能突触的神经介质,本文进一步报导Ach在脑内行使介质的作用以及药物对Ach在中枢中的合成、亚细胞分布、释放、再摄取以及更新等过程的最新资料。Ach作为中枢介质而发挥作用就是以上述过 Drugs acting directly or indirectly on the central nervous system are often used as a tool to explore the interrelationship between central function and biochemistry. Acetylcholine (Ach) has been shown to be the neural mediator of the peripheral cholinergic synapses. We further report the role of Ach in the mediation of the brain and the process by which the drug modulates Ach synthesis, subcellular distribution, release, reuptake, and renewal in the central nervous system The latest information. Ach as a central medium to play a role is described above