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研究了1974年在曼谷儿童医院的114例登革出血热病人,其中40%以上有登革休克综合征。这次研究包括有5例死亡病例。初次登革感染休克综合征的鉴别在于急性期血清缺乏抗体或抗体滴度低,而恢复期血清在 IgM 抗体升高之后继之以 IgG 抗体持续升高。3例(分别为4、8和12岁)为初次登革感染伴有休克,其他2例(分别为7和12岁)的恢复期血清虽然无法检验,但从死亡情况来看也属初次感染。初次感染的病人在休克时补体第三成分(C_3)的浓度低于正常。资料显示大年龄的儿童初次感染和再次感染一样,登革休克综合征的发生可能与补体降低有关。
Studied 114 cases of dengue haemorrhagic fever in Bangkok Children’s Hospital in 1974, of which over 40% had dengue shock syndrome. The study included 5 deaths. Initial dengue infection shock syndrome is characterized by the lack of serum antibody or antibody titer in the acute phase, while convalescent sera continues to rise following the rise of IgM antibody followed by IgG antibody. Three cases (4, 8 and 12 years old, respectively) had first-pass dengue infection with shock, while the other 2 cases (7 and 12 years, respectively) of convalescent sera, although not detectable, . Initial infection in patients with complement third component (C3) concentration is lower than normal. Data show that older children with primary infection and re-infection, the incidence of dengue shock syndrome may be related to reduced complement.