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前列腺素是一组在体内分布广泛,具有多种生物学活性和极高效价的物质。近年来,前列腺素、以及前列腺素和血小板在动脉粥样硬化发生发展中的作用有了进一步的认识,为动脉粥样硬化的防治开辟了一条新途径。 (一)前列腺素研究概况前列腺素是由多价不饱和脂肪酸形成的环戊烷衍生物。它的主要来源是花生四烯酸(AA)。AA存在于血小板及其他细胞膜的磷脂中。当某种因素激活了膜上的磷脂酶时,AA就从膜中释放出来。在体内,AA代谢有两条途径:一是脂氧化酶途径,另一个是
Prostaglandins are a group of substances that are widely distributed in the body and have a variety of biological activities and high potency. In recent years, prostaglandins, as well as prostaglandins and platelets in the development of atherosclerosis role has been further understanding of the prevention and treatment of atherosclerosis opened up a new way. (A) Prostaglandin Research Overview Prostaglandins are cyclopentane derivatives formed from polyunsaturated fatty acids. Its main source is arachidonic acid (AA). AA is present in the phospholipids of platelets and other cell membranes. When some factor activates the phospholipase on the membrane, AA is released from the membrane. In the body, there are two ways to metabolize AA: one is the lipoxygenase pathway and the other is