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目的探讨临床药师干预质子泵抑制剂使用的效果。方法选取2014年8月至2015年8月湖南省常宁市中医院诊治的80例使用质子泵抑制剂患者作为研究对象,按随机数字表法将其分为试验组和对照组,各40例。对照组患者遵医嘱用药,临床药师在患者用药过程中不予以任何干预,试验组患者给予临床药师干预,比较两组患者质子泵抑制剂使用情况及不良反应发生情况。结果试验组患者质子泵抑制剂用法不规范、用药过长、重复用药、过量用药、无指证用药及配伍发生率均明显低于对照组,差异均有统计学意义(均P<0.05);试验组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论在质子泵抑制剂使用过程中加强临床药师的干预,治疗效果理想,能够保证药物合理、有效的应用,降低药物不良反应的发生率。
Objective To investigate the effect of clinical pharmacists on the use of proton pump inhibitors. Methods Eighty patients with proton pump inhibitor diagnosed and treated in Changning Hospital of Traditional Chinese Medicine from August 2014 to August 2015 were selected as study subjects and divided into experimental group and control group according to random number table method, 40 cases in each group. Control group patients prescribed medication, clinical pharmacists in the course of the patient medication without any intervention, the experimental group of patients given clinical pharmacists intervention to compare the two groups of patients with proton pump inhibitor use and adverse reactions. Results The use of proton pump inhibitors in the test group was not standardized, the medication was overdose, repeated medication, overdose, no drug use and the compatibility rate were significantly lower than the control group (all P <0.05); test The incidence of adverse reactions in patients was significantly lower than that in the control group (P <0.05). Conclusion In the process of using proton pump inhibitors, the intervention of clinical pharmacists is strengthened and the treatment effect is satisfactory, which can ensure the rational and effective application of drugs and reduce the incidence of adverse drug reactions.