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目的:建立创愈生肌散的质量标准。方法:采用薄层色谱(TLC)法对本方中的川芎、当归、马钱子、白芷进行定性鉴别;采用高效液相色谱(HPLC)法对处方中主要成分阿魏酸进行含量测定。结果:在TLC色谱中可检出川芎、当归、马钱子、血竭、白芷,与其他组分良好分离;阿魏酸在0.03~0.5μg范围呈良好的线性关系,r=0.999 8,平均回收率103.19%,RSD为1.46%(n=6)。结论:所建立的方法简便可靠,准确性好,可用于该制剂的质量控制。
Objective: To establish the quality standard of Chuanshengjisan. Methods: Chuanxiong, Angelica, Strychnos and Angelica dahurica were identified by TLC. The content of ferulic acid in the prescription was determined by high performance liquid chromatography (HPLC). Results: Chuanxiong, Angelicae Sinensis, Strychnos nux - vomica, Radix Angelicae Sinensis and Radix Angelicae Sinensis could be detected by TLC. There was a good linear relationship between ferulic acid and other components in the range of 0.03-0.5 μg, r = 0.999 8, mean The recovery was 103.19% with a RSD of 1.46% (n = 6). Conclusion: The established method is simple and reliable, accurate and can be used for the quality control of the preparation.