论文部分内容阅读
目的 建立由物理因子诱发的骨肉瘤动物模型和瘤细胞模型 ,以及由化学因子诱发的肺癌动物模型 ,并研究其剂量 效应相关模式。方法 用放射性超铀核素2 3 8钚作为物理致癌因子在大鼠体内诱发骨肉瘤 ;从瘤组织中分离出瘤细胞系并研究其移植诱癌毒力用二苯并 [a ,h]蒽作为化学致癌因子 ,在小鼠体内诱发肺癌。研究上述两种致癌因子的剂量 效应相关模式。结果 上述两种致癌因子的剂量 效应相关模式都符合线性平方模型。结论 已建立的骨肉瘤动物模型和瘤细胞模型以及肺癌动物模型具有重要的理论意义和实际应用价值
Objective To establish animal models of osteosarcoma induced by physical factors and tumor cell models, as well as animal models of lung cancer induced by chemical factors, and to study their dose-effect related patterns. METHODS: Radioactive uranium 238 was used as a physical carcinogenic factor to induce osteosarcoma in rats. The tumor cell line was isolated from the tumor tissue and its tumorigenicity was studied with dibenzo[a,h]oxime. As a chemical carcinogen, lung cancer is induced in mice. To study the dose-effect related patterns of the above two carcinogenic factors. Results The dose-effect correlation patterns of the above two carcinogenic factors all met the linear square model. Conclusion The established osteosarcoma animal model and tumor cell model and lung cancer animal model have important theoretical significance and practical application value.