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目的通过分析氨甲环酸(tranexamic acid,TXA)对人工全膝关节置换术(total knee arthroplasty,TKA)隐性失血的影响,探讨其止血疗效.方法:对拟行初次TKA的92例膝骨关节炎患者进行分组,观察组46例在松止血带时将lgTXA用250ml生理盐水稀释后静滴,3h后重复给药,对照组46例在相应时间予等剂量生理盐水静滴,比较两组术中失血量、术后引流量、隐性失血量与输血量.结果:两组术后引流量、隐性失血量和输血量比较,差异均有统计学意义(P＜0.05).结论:TXA可以显著减少初次人工全膝关节术的隐性失血量.","Objective To evaluate the effect of tranexamic acid(TXA) on hidden blood loss in total knee arthroplasty(TKA). Methods 92 patients with osteoarthritis of the knee undergoing primary TKA were devided into two groups. In the observation group, 46 cases received the infusion of 1 gTXA with 250 mL normal saline in the pine touiquet, and then repeated after 3 h. 46 cases in the control group were given equal dose of normal saline at the corresponding time. The intraoperative blood loss, postoperative drainage volume, hidden blood loss, transfusion volume after operation were compared between the two groups. Results The difference of postoperative drainage volume, hidden blood loss, transfusion volume after operation in the two groups were statistically significant (P＜0.05). Conclusion TXA could significantly reduced hidden blood loss in primary TKA.