论文部分内容阅读
分析２２例临床有或疑有神经系统损害的系统性红斑狼疮（ＳＬＥ）患者，其中仅３例被临床诊断为ＳＬＥ合并周围神经病，然神经电生理检查证实１３例为周围神经损害。主要临床特点为对称性和非对称性四肢远端麻木、疼痛，深浅感觉障碍，肌力减退，肌萎缩等。神经电生理检查显示神经传导速度减慢，波幅降低，异常自发电位（纤颤电位和正锐波），运动单元多相电位增加。电生理检查与病理改变相符：ＳＬＥ合并周围神经病既有轴索损害，又有脱髓鞘改变。提示神经电生理检查可以为ＳＬＥ患者提供早期或亚临床周围神经损害的依据。
Twenty-two patients with systemic lupus erythematosus (SLE) who had or suspected neurological damage were analyzed. Only 3 of them were clinically diagnosed as SLE complicated by peripheral neuropathy, and nerve electrophysiological examination confirmed 13 cases of peripheral nerve damage. The main clinical features of symmetry and asymmetry distal limb numbness, pain, depth sensory disturbances, muscle weakness, muscle atrophy and so on. Nerve electrophysiological examination showed slowing of nerve conduction velocity, reduced amplitude, abnormal spontaneous potentials (fibrillation potentials and positive sharp waves), and multiphase potentials of motor units increased. Electrophysiological examination and pathological changes in line with: SLE with peripheral neuropathy both axonal damage, there are demyelinating changes. It is suggested that neuroelectrophysiological examination can provide evidence of early or subclinical peripheral nerve damage in SLE patients.