Multi-user detection (MUD) based on multirate transmission in code division multiple access (CDMA) system is discussed. Under the requirement of signal interference ratio (SIR) detection at base station and framework with parallel interference cancellation, a supervision decision algorithm based on pre-decision of probabilistic data association (PDA) and hard decision is proposed. The detection performance is analyzed and simulation is implemented to show that the supervision decision algorithm improves the detection performance effectively. Multi-user detection (MUD) based on multirate transmission in code division multiple access (CDMA) system is discussed. Under the requirement of signal interference ratio (SIR) detection at base station and framework with parallel interference cancellation, a supervision decision algorithm based on pre-decision of probabilistic data association (PDA) and hard decision is proposed. The detection performance is analyzed and simulation is implemented to show that the supervision decision algorithm improves the detection performance effectively.