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目的探讨缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)表达及其与肺癌生物学行为的相关性。方法采用免疫组织化学方法对68例肺癌组织和50例正常肺组织的HIF-1α及VEGF进行检测。结果肺癌组织中HIF-1α阳性率为69.1%,显著高于正常肺组织(P<0.01);肺癌组织与正常肺组织中VEGF阳性率分别为70.6%和4.0%,差异有统计学意义(P<0.01);HIF-1α和VEGF表达与肺癌组织的临床分期、组织分化及淋巴转移密切相关(P<0.05);肺癌组织HIF-1α和VEGF的表达显著相关(P<0.05)。结论 HIF-1α和VEGF参与了肺癌的发生发展,与肿瘤组织分化、侵袭转移等生物学行为密切相关,可作为反映肺癌预后的重要指标。
Objective To investigate the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) and its correlation with the biological behavior of lung cancer. Methods Immunohistochemistry was used to detect HIF-1α and VEGF in 68 cases of lung cancer and 50 cases of normal lung tissues. Results The positive rate of HIF-1α in lung cancer tissues was 69.1%, which was significantly higher than that in normal lung tissues (P <0.01). The positive rates of VEGF in lung cancer tissues and normal lung tissues were 70.6% and 4.0%, respectively <0.01). The expression of HIF-1α and VEGF was closely related to the clinical stage, differentiation and lymph node metastasis of lung cancer (P <0.05). Conclusions HIF-1α and VEGF are involved in the occurrence and development of lung cancer. They are closely related to the biological behaviors such as differentiation, invasion and metastasis of tumor, which may be used as an important index to reflect the prognosis of lung cancer.