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外耳道乳头状瘤,国内较为常见,病因不明,疑由人乳头瘤病毒(HPV)引起,但未能证实。我们对14例外耳道乳头状瘤患者的15个标本进行了研究。男性11例,女性3例,年龄分布28～67岁,平均46岁。患者均有挖耳习惯,临床表现为外耳道软骨壁有黄豆大淡红色或黄褐色新生物。 超微结构改变:电镜下见多数病例角质层增厚,角化细胞内见残余细胞核,颗粒层见散在空泡细胞,透明角质颗粒减少,甚至消失。棘细胞层见散在或局灶性分布的空泡细胞,胞浆内线粒体肿胀呈空泡状,基质颗粒消失。内浆网扩张呈囊泡状,糖原颗粒减少,甚或消失,张力微丝呈细束状。细胞核少数有畸形、染色质呈小粒状散在于常染色质问,核仁明显。3万倍以上观察在空泡化细胞内未找见典型病毒颗粒,仅见核内染色质间颗粒增多,染色质周围颗粒及核小体易见,基底细胞层未见明显异常。
External auditory canal papilloma, more common in China, the etiology is unknown, suspected by the human papillomavirus (HPV) caused, but failed to confirm. We studied 15 specimens of 14 patients with external auditory canal papilloma. There were 11 males and 3 females, with a mean age of 46 years ranging from 28 to 67 years. Patients have the habit of digging ears, the clinical manifestations of the outer ear cartilage wall with large reddish brown or yellow new creatures. Ultrastructural changes: electron microscopy see the majority of cases stratum corneum thickening, keratinocytes see residual nuclei, granular layer see scattered in vacuolar cells, transparent keratin particles decreased, or even disappear. Spin-cell layer see scattered or focal distribution of vacuolar cells, cytoplasm mitochondria were vacuolar swelling, matrix particles disappear. Bladder within the cystic dilatation expansion, glycogen particles reduce, or even disappear, tension filaments were thin beam. Minorities of the nucleus have deformities, chromatin was scattered in small euchromatin ask, obvious nucleoli. 30,000 times more than the observation in the vacuole cells found no typical virus particles, only the inter-nuclear chromatin particles increased, the chromatin around the nuclei and nucleosomes easily visible basal cell layer no significant abnormalities.