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目的 探讨亚低温治疗对急性脑梗死患者血抗利尿激素 (ADH)、血管紧张素 (AII)及醛固酮(ALD)的影响及在临床中的意义。方法 动态监测 6 0例急性脑梗死患者亚低温及常规治疗时血ADH、AII、ALD的变化规律及治疗前后神经功能缺损评分。结果 亚低温治疗较常规治疗能明显降低患者血中ADH、AII、ALD的水平 ,降低神经功能缺损评分 ,两组比较有显著性差异 (P <0 .0 5～ 0 .0 1)。结论 亚低温治疗可明显降低急性脑梗死患者血ADH、AII及ALD水平 ,降低神经功能缺损评分和应激激素水平 ,减轻应激反应 ,防治脑水肿 ,保护脑组织 ,改善预后。
Objective To investigate the effects of mild hypothermia therapy on serum anti-diuretic hormone (ADH), angiotensin (AII) and aldosterone (ALD) in patients with acute cerebral infarction and its clinical significance. Methods The changes of blood ADH, AII and ALD in 60 mild acute cerebral infarction patients during the mild hypothermia and routine treatment were monitored dynamically and the neurological impairment scores were measured before and after treatment. Results Compared with conventional treatment, mild hypothermia can significantly reduce the levels of ADH, AII and ALD in blood and reduce the score of neurological deficit in both groups (P <0.05-0.01). Conclusion Mild hypothermia can significantly reduce blood levels of ADH, AII and ALD in patients with acute cerebral infarction, reduce neurological deficit score and stress hormone levels, reduce stress response, prevent cerebral edema, protect brain tissue and improve prognosis.