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目的:采用Meta分析探讨单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)基因的G2518A位点及趋化因子受体2(CC chemokine receptor 2,CCR2)基因的G190A位点多态性与冠状动脉疾病(coronary artery disease,CAD)的关联性。方法:通过PubMed,EMbase,CNKI及CBM等数据库搜索关于MCP-1/CCR2基因多态性与CAD关联性的文章。结果:符合纳入标准的共有21篇文献,MCP-1基因的G2518A位点和CCR2基因的G190A位点分别有6 835例CAD患者、11 142例正常对照受试者,以及2 801例CAD患者、5 789例正常对照受试者入选。综合数据表明MCP-1基因的G2518A位点和CCR2基因G190A位点多态性与CAD的发生存在关联[G2518A(P=0.04),G190A(P=0.005)]。根据分层分析观察到MCP-1基因的G2518A位点在非亚洲人群中与CAD存在关联性(P=0.04),而在亚洲人群中与CAD不具有统计学意义(P>0.05)。结论:MCP-1基因的G2518A位点及CCR2基因的G190A位点多态性与CAD的发生具有统计学意义。
OBJECTIVE: To investigate the relationship between the G1918A site of G2518A and CC chemokine receptor 2 (CCR2) gene of monocyte chemotactic protein-1 (MCP-1) gene by Meta-analysis Association of polymorphisms with coronary artery disease (CAD). Methods: A database of MCP-1 / CCR2 genetic polymorphisms associated with CAD was searched using databases such as PubMed, EMbase, CNKI and CBM. RESULTS: A total of 21 articles met the inclusion criteria. The G2518A locus of MCP-1 gene and G190A locus of CCR2 gene were 6 835 CAD patients, 11 142 normal control subjects and 2 801 CAD patients, respectively. 5 789 normal control subjects were enrolled. The results showed that the G2518A locus of MCP-1 gene and the G190A locus of CCR2 gene were associated with the occurrence of CAD [G2518A (P = 0.04), G190A (P = 0.005)]. According to stratified analysis, G2518A locus of MCP-1 gene was found to be associated with CAD in non-Asian population (P = 0.04), but not in CAD with Asian population (P> 0.05). Conclusion: G2518A locus of MCP-1 gene and G190A polymorphism of CCR2 gene have statistical significance with the occurrence of CAD.