Objective To explore the adsorption properties for the separation of apigenin from Viola yedoensis on LSA-10 resin.Methods After different types of macroporous resins were optimized,the effects of initial concentration,temperature,pH value,and other factors on resin adsorption were studied,and the kinetics and thermodynamics in the process of the static adsorption of LSA-10 resin for the apigenin separation from V.yedoensis were also investigated.Results The initial concentration of 4.0 mg/mL,temperature of 50 oC,and pH 5 were suitable for the resin adsorption,the experimental data of adsorption isotherms of LSA-10 resin were validated to fit the Freunclich and Langmuir equation,the adsorption process of apigenin was fitted to the first order adsorption kinetics equation,and the adsorption rate was mainly affected by film diffusion.The thermodynamic parameters such as adsorption enthalpy change(ΔH>0),adsorption free energy change(ΔG<0),and adsorption entropy change(ΔS>0)were investigated.Conclusion The adsorption for the separation of apigenin on LSA-10 resin was an entropy-driven spontaneous process of decalescence and entropy increase,which belongs to physical adsorption.LSA-10 resin is suitable for the industrial separation of apigenin from V.yedoensis. Objective To explore the adsorption properties for the separation of apigenin from Viola yedoensis on LSA-10 resin. Methods After different types of macroporous resins were optimized, the effects of initial concentration, temperature, pH value, and other factors on resin adsorption were studied, and the kinetics and thermodynamics in the process of the static adsorption of LSA-10 resin for the apigenin separation from V.yedoensis were also investigated. Results of the initial concentration of 4.0 mg / mL, temperature of 50 oC, and pH 5 were suitable for the resin adsorption, the experimental data of adsorption isotherms of LSA-10 resin were validated to fit the Freunclich and Langmuir equation, the adsorption process of apigenin was fitted to the first order adsorption kinetic equation, and the adsorption rate was mainly affected by film diffusion The thermodynamic parameters such as adsorption enthalpy change (ΔH> 0), adsorption free energy change (ΔG <0), and adsorption entropy change (ΔS> 0) were investi gated.Conclusion The adsorption for the separation of apigenin on LSA-10 resin was an entropy-driven spontaneous process of decalescence and entropy increase, which belongs to physical adsorption. LSA-10 resin is suitable for the industrial separation of apigenin from V.yedoensis .