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瘦素是近五年来发现的一种具有重要生物活性的多肽类激素。瘦素与肾脏的关系密切 :肾脏是瘦素清除的主要器官 ,同时瘦素又可对肾脏直接发挥作用。瘦素在肾脏病生理过程中的作用是值得研究的课题。目前认为瘦素是慢性肾功能不全 (CRF)时体内聚积的毒素之一 ,研究清除瘦素的方法对于提高CRF病人的生存质量 ,预防并发症有重要意义。
Leptin is a kind of peptide hormone with important biological activity discovered in recent five years. Leptin and the kidney are closely related: the kidneys are the main organs of leptin removal, while leptin can play a direct role in the kidneys. The role of leptin in the physiology of kidney disease is worth studying. At present, leptin is considered as one of the toxins accumulating in the body during chronic renal insufficiency (CRF). To study the method of removing leptin is of great significance for improving the quality of life and preventing complications of patients with CRF.