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目的 :探讨激素性股骨头缺血坏死 (简称 INFH)中内皮素 (简称 ET)、血栓烷 (简称 TXA2 )、前列环素 (简称 PGI2 )的变化及中药作用。方法 :选用 60只兔分 7组造成 INFH模型 ,中药治疗后观察反映血管内皮的各项指标。结果 :(1 )激素可造成血管内皮损伤 ;(2 )活血、祛痰法早期可能损伤血管内皮 ,补肾法可减缓内皮损伤。结论 :(1 ) ET可作为反映骨坏死的一个早期指标 ;(2 ) PGI2 /TXA2 的平衡在骨坏死中起一定作用。(3)提示早期预防的重要性
Objective: To investigate the changes of endothelin (ET), thromboxane (TXA2) and prostacyclin (PGI2) in steroid-induced avascular necrosis of the femoral head (referred to as INFH) and the effects of traditional Chinese medicine. Methods: Sixty-five rabbits were divided into 7 groups to produce the INHH model. After the treatment of traditional Chinese medicine, the indexes reflecting the vascular endothelium were observed. Results: (1) Hormones can cause damage to vascular endothelium; (2) Blood circulation and decoction can damage the vascular endothelium in the early stage. The kidney-supplemented method can reduce endothelial damage. Conclusion : (1) ET can be used as an early indicator of bone necrosis. (2) The balance of PGI2/TXA2 plays a role in osteonecrosis. (3) The importance of early prevention