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[目的 ]研究活血化瘀开窍法对脑缺血再灌注模型大鼠脑组织一氧化氮合成酶 ( NOS)及自由基的影响。 [方法 ]48组大鼠随机分为 6组 ,脑醒冲剂高、中、低剂量组、尼莫通组、模型组、假手术组 ,分别测定 NOS、 LPO、 SOD、 GSH- Px,并作统计学处理。 [结果 ]活血化瘀开窍中药能适度提升脑组织 NOS浓度 ,并能提高 SOD、 GSH- Px的活性 ,降低 LPO水平 (与模型组比较 ,P <0 .0 1或 P <0 .0 5 )。 [结论 ]活血化瘀方药对大鼠急性缺血再灌注脑损伤具有保护作用
[Objective] To study the effects of promoting blood circulation, resolving phlegm, and resolving phlegm on brain tissue nitric oxide synthase (NOS) and free radicals in rats with cerebral ischemia-reperfusion. [Methods] 48 groups of rats were randomly divided into 6 groups: Naoxing Granules high, middle and low dose group, Nimotop group, model group and sham operation group. NOS, LPO, SOD, GSH-Px were measured. Statistical processing. [Results] Traditional Chinese herbs can improve the NOS concentration in brain tissue, increase the activity of SOD and GSH-Px, and decrease the LPO level (P<0.01 or P<0.05 compared with the model group). . [Conclusion] Huoxue Huayu Recipe has a protective effect on acute cerebral ischemia-reperfusion injury in rats