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对文献报道的实验反应条件进行优化改进后,合成了不对称加氢催化剂[Ru((S)-BINAP)(OAc)2]和[Ru((R)-BINAP)(OAc)2]。将合成的催化剂应用于惕各酸的不对称催化氢化,(S)-2-甲基丁酸得率为88%,立体选择性可达85%e.e.。为了提高催化剂的利用率,将催化剂[Ru(BINAP)(OAc)2]负载在新型介孔分子筛SBA-15上,用于惕各酸的不对称催化氢化,循环应用3次后,(S)-2-甲基丁酸得率仍可达到59%,立体选择性达57%e.e.。
The asymmetric hydrogenation catalysts [Ru ((S) -BINAP) (OAc) 2] and [Ru ((R) -BINAP) (OAc) 2 were synthesized by optimizing the experimental reaction conditions reported in the literature. The synthesized catalyst was applied to the asymmetric catalytic hydrogenation of tiglic acid. The yield of (S) -2-methylbutanoic acid was 88% and the stereoselectivity was 85% e.e. In order to improve the utilization of the catalyst, the catalyst [Ru (BINAP) (OAc) 2] was supported on a novel mesoporous molecular sieve SBA-15 for asymmetric catalytic hydrogenation of tiglic acid. Methylbutanoic acid was still 59% yield, stereoselectivity up to 57% ee.