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为了合理利用甾体皂甙元资源,系统地考察了16R-溴代孕甾-3S,20S-二醇二乙酸酯在不同反应条件下与碱的反应.给出了选择性地分别转化16R-溴代孕甾-3S,20S-二醇二乙酸酯成为孕甾-16-烯-3S,20S-二醇二乙酸酯、16R-溴代孕甾-3S,20S-二醇、孕甾-3S,16S,20S-三醇、孕甾-14,16-二烯-3S-醇乙酸酯和雄甾-16-烯-3S-醇等化合物的可控性反应结果.这些条件可控性反应结果不仅为甾体药物和生物活性天然甾体化合物合成提供了新的合成中间体,也为它们新合成策略和途径的设计提供了机遇.
In order to utilize the steroid saponin resources rationally, the reaction of 16R-bromopregn-3S, 20S-diol diacetate with a base under different reaction conditions was systematically investigated, and the selective reaction of 16R-bromine Pregsta-3S, 20S-diol diacetate becomes pregnen-16-ene-3S, 20S-diol diacetate, 16R-bromopregna-3S, 20S-diol, 16S, 20S-triol, pregna-14,16-diene-3S-ol acetate, and androsta-16-ene-3S-ol, etc. These conditional controllable reaction results not only Provide new synthetic intermediates for the synthesis of steroidal drugs and bioactive natural steroids and also provide opportunities for the design of their new synthetic strategies and approaches.