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目的探讨钴铬合金烤瓷冠和全瓷冠修复对患牙牙周组织及龈沟液(GCF)中炎症因子水平的影响。方法选择2014年9月至2015年3月来内蒙古赤峰市医院口腔科就诊的67例上颌前牙牙体缺损需行全冠修复的患者(共97颗患牙),将所有患牙随机分配到钴铬合金烤瓷冠组(A组,42颗)和全瓷冠组(B组,55颗)。于修复前、修复后1个月、3个月测定患牙牙周组织各项指标[包括牙龈指数(GI)、龈沟探诊深度(GCD)、GCF量]及GCF中白细胞介素(IL)-8、基质金属蛋白酶(MMP)-8和肿瘤坏死因子(TNF)-α的水平。结果修复前A、B两组间患牙牙周组织各项指标(GI、GCD、GCF量)及GCF中IL-8、MMP-8和TNF-α的水平差异均无统计学意义。对比修复前,修复后1个月和3个月时间点,A、B两组患牙牙周组织各项指标(GI、GCD、GCF量)以及GCF中IL-8、MMP-8和TNF-α的水平差异均有统计学意义(P<0.05)。修复后1个月,A、B两组间患牙GCF中IL-8、MMP8及TNF-α的水平差异有统计学意义(P<0.05),而牙周组织各项指标(GI、GCD、GCF量)差异无统计学意义(P>0.05)。修复后3个月,A、B两组间患牙牙周组织各项指标(GI、GCD、GCF量)及GCF中IL-8、MMP-8和TNF-α的水平差异均有统计学意义(P<0.05)。结论采用钴铬合金烤瓷冠可导致患牙牙周GCF量及GCF中炎症因子水平的升高,不利于牙周组织的恢复,远期治疗效果欠佳,全瓷冠对局部牙周组织影响相对较小,远期疗效好。
Objective To investigate the effects of cobalt-chromium alloy porcelain crowns and all-ceramic crowns on inflammatory cytokines in periodontal tissues and gingival crevicular fluid (GCF). METHODS: From September 2014 to March 2015, 67 cases of maxillary anterior dental defects requiring total crown restoration (total 97 teeth) were treated in the Department of Stomatology, Chifeng Hospital, Inner Mongolia. All the teeth were randomly allocated to cobalt Chromium alloy porcelain crown group (A group, 42) and all-ceramic crown group (B group, 55). The indexes of periodontal tissues (including gingival index (GI), gingival crest depth (GCD) and GCF) and GCF interleukin (IL) levels were measured at 1 month and 3 months after repair. ) -8, matrix metalloproteinase (MMP) -8 and tumor necrosis factor (TNF) -alpha. Results There was no significant difference in the levels of IL-8, MMP-8 and TNF-α in the periodontal tissues between the two groups before repair (P <0.05). The levels of IL-8, MMP-8 and TNF-αin GCF were compared between the two groups at each time points of 1 month and 3 months after repair. The indexes of periodontal tissues (GI, GCD and GCF) α levels were statistically significant differences (P <0.05). The level of IL-8, MMP-8 and TNF-α in GCF at 1 month after repair was significantly different between groups A and B (P <0.05), while the indexes of periodontal tissues (GI, GCD, GCF amount) was no significant difference (P> 0.05). At 3 months after repair, the levels of IL-8, MMP-8 and TNF-α in periodontal tissues (GI, GCD and GCF) and GCF in groups A and B were significantly different (P <0.05). Conclusion The use of cobalt-chromium alloy porcelain crowns can lead to GCF amount of periodontal ligament and GCF inflammatory cytokines levels rise is not conducive to the recovery of periodontal tissue, long-term treatment ineffective, all-ceramic crown on the local periodontal tissue Relatively small, long-term effect is good.