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The antioxidant ability of capsules containing oats avenanthramides on human body was evaluated in present study.Healthy people were randomized to supplementation with oats-derived avenanthramides capsules or placebo for 1 mon.Plasma lipid peroxides and antioxidant status were measured.For 8 capsules (containing 3.12 mg avenanthramides)groups,the levels of serum superoxide dismutase (SOD) and reduced glutathione hormone (GSH) were significantly increased by 8.4 and 17.9％,respectively (P＜0.05),and malondialdehyde (MDA) level significantly decreased by 28.1％.The total cholesterol (TC),triglyceride (TG),and low density lipoprotein cholesterol (LDL-C) levels were lowered by 11.1,28.1,and 15.1％,respectively (P＜0.05).The high density blood lipoprotein cholesterol (HDL-C) levels in the same treat was increased by 13.2％.Based on our research,it can be concluded that oats extract containing avenanthramides possessed a high antioxidative activity on humans.It indicated that oat avenanthramides could be used to prevent hyperlipemic and angiocardiopathy.