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目的探讨米非司酮联合依沙吖啶用于瘢痕子宫中晚期妊娠引产的临床效果。方法选取瘢痕子宫中晚期妊娠引产患者76例,随机分为观察组和对照组各38例,对照组采单纯用依沙吖啶羊膜腔注射引产,观察组采用米非司酮联合依沙吖啶引产,比较两组的引产成功率、引产效果、不良反应及并发症发生情况。结果观察组引产成功率为100%,明显高于对照组的94.74%(P<0.05);观察组的平均宫缩发动时间、宫缩至胎盘娩出时间均明显短于对照组(P<0.05),胎盘胎膜残留率及阴道出血量均明显低于对照组(P<0.05)。对照组38例患者中7例出现宫颈裂伤,观察组无宫颈裂伤发生;两组均未发生产后感染、羊水栓塞、子宫破裂和大出血等并发症。结论米非司酮联合依沙吖啶用于瘢痕子宫中晚期妊娠引产安全性好、使用方便、并发症少、无明显不良反应、患者痛苦小,是临床上一种较为理想的瘢痕子宫的引产方法。
Objective To investigate the clinical effect of mifepristone combined with ethacridine on induced abortion in middle and late stage of uterine scar. Methods 76 cases of induced abortion in middle and late pregnancy with scar uterus were randomly divided into observation group and control group, 38 cases in each group. The control group was treated with amniotic fluid injection alone. The observation group was treated with mifepristone combined with ethacridine Induction of labor, compared the success rate of induction of labor, labor induction, adverse reactions and complications occurred. Results The success rate of induction of labor in the observation group was 100%, which was significantly higher than that in the control group (94.74%, P <0.05). The average duration of contractions and contractions of the contractions in the observation group were significantly shorter than those in the control group (P <0.05) , The residual rate of fetal membranes and vaginal bleeding were significantly lower than the control group (P <0.05). Cervical laceration occurred in 7 of the 38 patients in the control group and no cervical laceration occurred in the observation group; complications such as postnatal infection, amniotic fluid embolism, rupture of the uterus, and bleeding were not observed in both groups. Conclusions Mifepristone combined with ethacridine is safe and easy to use for induction of labor in the middle and late stage of uterine scar pregnancy with few complications and no obvious adverse reactions. It is a clinically preferable type of labor for induced abortion of scarring uterus method.