研究了在La(OTf)3的催化条件下,以丙二酸和酮为原料,缩合反应合成了3种1,3-二噁烷-4,6-二酮化合物.考察了酸酮物质的量之比、反应温度、反应时间、催化剂用量及催化剂的稳定性等因素对反应的影响.确定了其最佳反应条件为:取0.1mol丙二酸,n(丙二酸)∶n(酮)=1.0∶1.1,催化剂用量为0.3mol%,反应温度30℃,反应时间为3.0h,在上述反应条件下,产品收率可达62.3%～77.5%. Under the catalysis conditions of La (OTf) 3, three kinds of 1,3-dioxane-4,6-dione compounds were synthesized through condensation reaction with malonic acid and ketone as raw materials. The reaction temperature, the reaction time, the amount of catalyst and the stability of the catalyst on the reaction.The optimum reaction conditions were as follows: 0.1 mol of malonic acid, n (malonic acid): n ) = 1.0:1.1, the amount of catalyst is 0.3mol%, the reaction temperature is 30 ℃ and the reaction time is 3.0h. Under the above reaction conditions, the product yield can reach 62.3% ~ 77.5%.