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目的:探讨多巴胺并卡托普利治疗小儿急性肾小球肾炎的临床疗效。方法:选取2012年3月~2014年3月在我院因“急性肾小球肾炎”治疗的80例患儿,采用完全随机分组法。其中对照组40例予“基础治疗+卡托普利”治疗,观察组40例予“基础治疗+卡托普利+多巴胺”治疗。观察并两组患儿水肿消退的时间(T1)、24h尿蛋白量转阴的时间(T2)及患者住院的天数(T3)及患者住院时和出院时血清中C-反应蛋白量的比较。结果:观察组水肿消退的时间(T1)、24h尿蛋白量转阴的时间(T2)及患者住院的天数(T3)短于对照组,两组T1、T2、T3之间的差异(P<0.05)。观察组血清C-反应蛋白量的变化明显高于对照组。经统计分析,两组治疗后血清C-反应蛋白量之间的差异(P<0.05)。对照组总有效率为80.0%,观察组总有效率为95.0%;两组总有效率之间的差异(P<0.05)。结论:多巴胺并卡托普利治疗小儿急性肾小球肾炎的临床疗效显著,能明显缩短患儿水肿消退的时间、24h尿蛋白量转阴的时间以及住院的天数;同时降低患者的应激水平。值得临床参考。
Objective: To investigate the clinical efficacy of dopamine and captopril in the treatment of pediatric acute glomerulonephritis. Methods: Eighty children with acute glomerulonephritis treated in our hospital from March 2012 to March 2014 were selected and randomly divided into groups. 40 cases in the control group were treated with “basic therapy + captopril” and 40 cases in the observation group were treated with “basic therapy + captopril + dopamine”. The time to edema (T1), the time of negative urine protein (T2), the number of days hospitalized (T3) and the serum levels of C-reactive protein in hospital were compared between the two groups. Results: The edema time (T1), urinary protein 24 h (T2) and hospitalization days (T3) in the observation group were shorter than those in the control group. There was significant difference between the two groups in T1, T2 and T3 (P < 0.05). The change of serum C-reactive protein in the observation group was significantly higher than that in the control group. After statistical analysis, the difference between the two groups after treatment of serum C-reactive protein (P <0.05). The total effective rate was 80.0% in the control group and 95.0% in the observation group. The difference between the two groups was significant (P <0.05). Conclusions: The therapeutic effect of dopamine and captopril in children with acute glomerulonephritis is significant, which can significantly shorten the time of edema, the time of 24-hour urine protein negative conversion and the number of days of hospitalization, and reduce the stress level in patients . Worthy of clinical reference.