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目的:分析IgG4相关唾液腺炎和有“唾液腺肿大”类似表现的常见唾液腺非肿瘤疾病的特点,明确其临床鉴别诊断要点。方法:回顾分析诊断为IgG4相关唾液腺炎患者的临床资料,与有腺体肿大类似表现的唾液腺非肿瘤疾病进行比较,重点从病史及临床表现、血液免疫学和组织病理学方面比较IgG4相关唾液腺炎与舍格伦综合征(Sjogren’ssyndrome,SS)的差异,应用SAS8.0软件包对数据进行非参数统计。结果:335例唾液腺非肿瘤疾病患者纳入本研究,包括IgG4相关唾液腺炎25例、阻塞性唾液腺炎279例和SS31例。比较IgG4相关唾液腺炎与阻塞性唾液腺炎和SS的疾病特点可见,其在病史及临床检查、血液免疫学和组织病理学等方面均有各自特点,差异显著。结论:IgG4相关唾液腺炎是一类以唾液腺肿大为典型表现的唾液腺慢性炎症,临床上应综合多方面考虑,与其他可能引起唾液腺肿大症状的疾病明确鉴别,准确诊断,为进一步制订合理的治疗方案提供依据。
OBJECTIVE: To analyze the characteristics of IgG4 related salivary gland inflammation and common salivary gland non-tumor diseases with similar manifestations of “salivary gland enlargement,” and to clarify the main points of its clinical differential diagnosis. METHODS: The clinical data of patients diagnosed with IgG4-associated salivary gland inflammation were retrospectively analyzed and compared with salivary gland non-neoplastic disease with similar glandular enlargement, with a focus on history and clinical presentation, hematological immunology, and histopathology to compare IgG4-associated salivary glands Differences between Sjogren’s Syndrome and Sjogren’s Syndrome (Sjogren’s Syndrome) were analyzed using SAS 8.0 software package. RESULTS: A total of 335 patients with salivary gland non-neoplastic disease were enrolled in this study, including 25 cases of IgG4-associated salivary gland disease, 279 cases of obstructive salivary gland disease and 31 cases of SS. Comparison of IgG4-related salivary gland inflammation and obstructive salivary inflammation and SS disease characteristics can be seen in its history and clinical examination, hematological immunology and histopathology and other aspects have their own characteristics, the difference was significant. Conclusion: IgG4-related salivary gland inflammation is a type of chronic inflammation of salivary glands characterized by salivary gland enlargement. It should be considered comprehensively in various aspects and be clearly identified and diagnosed with other diseases that may cause salivary gland swelling symptoms. In order to further develop a reasonable Treatment programs provide the basis.