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氯喹在尼日利亚是最廉、使用最广的抗疟药,但在东非、中非和西非有抗氯喹恶性疟的报道。为了查明尼日利亚有无抗氯喹的疟疾,在贡戈拉南部高原热带雨林区的贝萨农村,对氯喹治疗儿童疟疾的功效进行了研究。患儿年龄为6～59个月。从每个儿童采指血制成厚血膜染色和镜检估计疟原虫密度。研究的儿童必须在检查前7天内无服抗疟药史,并在检查后的14天内不擅自在家服用任何药物;在实验室检查方面必须是Dill Glazko法尿检氯喹阴性和血检无性体恶性疟原虫≥1600/mm~3者。严重病儿,尤其是其他病因引起的病儿不参加研究。在筛选的769
Chloroquine is the cheapest and most widely used anti-malaria drug in Nigeria, but there are reports of resistance to chloroquine-resistant falciparum in East, Central and West Africa. In order to ascertain whether there is any chloroquine-resistant malaria in Nigeria, the efficacy of chloroquine in the treatment of childhood malaria was studied in the Bezac countryside in the tropical rainforest zone of the southern plateau of Gongora. Children aged 6 to 59 months. Blood samples were taken from each child for thick film staining and microscopic examination to estimate the density of the parasite. The study children must have no history of anti-malaria drugs within 7 days prior to the test and should not take any medication at home within 14 days of the test. They must be Dill Glazko urine tests for chloroquine-negative and blood tests for falciparum falciparum Protozoa ≥ 1600 / mm ~ 3. Serious sick children, especially those caused by other causes do not participate in the study. In the screening of 769