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目的 :揭示补阳还五汤及拆方抗脑缺血再灌注损伤的作用机理。方法 :通过四血管结扎法制作SD大鼠脑缺血再灌注模型 ,观察总方组与拆方黄芪组、活血组药物对模型血浆血栓素B2 (TXB2 )、6 -酮 -前列腺素F1a (6 -Keto-PGF1a)含量的影响。结果 :模型组大鼠血浆TXB2 含量明显增高 ,6 -Keto -PGF1a含量明显降低 ;总方组与拆方黄芪组、活血组均能降低TXB2 含量 ,升高 6 -Keto-PGF1a含量 ,总方组作用最强。结论 :补阳还五汤及拆方具有通过影响花生四烯酸的代谢产物血栓素B2、6 -Keto -PGF1a含量 ,从而达到抗脑缺血再灌注损伤的作用。总方组的疗效明显优于拆方组
Objective: To reveal the mechanism of Buyang Huanwu Decoction and its decoction on cerebral ischemia reperfusion injury. METHODS: SD rat cerebral ischemia-reperfusion model was established by four-vessel ligation method. The total thromboxane B2 (TXB2) and 6-keto-prostaglandin F1a in the model group were compared with those in the disassembled Astragalus membranaceus group and Huoxue group. Effect of -Keto-PGF1a) content. RESULTS: Plasma TXB2 content in the model group was significantly increased, and 6-Keto-PGF1a content was significantly decreased. TXG2 content was decreased in the Fangfang group, Diterpenes Huangqi group and Huoxue group, and the content of 6-Keto-PGF1a was increased. The strongest role. Conclusion: Buyang Huanwu Decoction and its decoction have the effect of anti-cerebral ischemia reperfusion injury by affecting the content of thromboxane B2,6-Keto-PGF1a metabolites of arachidonic acid. The efficacy of the total prescription group is significantly better than the deconstructive group