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急性冠脉综合征(acu te coronary syndrom es,ACS)是最常见的心血管系统疾病之一,包括不稳定性心绞痛(UA)、Q波型心肌梗死(QM I)和非Q波型心肌梗死(NQM I)及心源性猝死(CSD)。近年来,大量的基础研究发现其发病机理与不稳定斑块的破裂有密切关系,且与多种血清标志物密切相关。对其进行明确诊断及危险评估对临床治疗有重要指导意义。ACS的治疗包括手术治疗和非手术治疗,随着对ACS研究认识的深入,不断开发出一些新的治疗措施,如新型抗血栓药物及基因治疗等。本文就ACS的发病机制、诊断、血清标志物和治疗综述如下。
Acute coronary syndrome (ACS) is one of the most common cardiovascular diseases, including unstable angina (UA), Q-wave myocardial infarction (QM I) and non-Q-wave myocardial infarction (NQM I) and sudden cardiac death (CSD). In recent years, a large number of basic research found that its pathogenesis is closely related to the rupture of unstable plaque, and is closely related to a variety of serum markers. To carry out a clear diagnosis and risk assessment of the clinical treatment has important guiding significance. ACS treatment includes surgical treatment and non-surgical treatment, with the deepening understanding of ACS research and development of new treatments, such as new antithrombotic drugs and gene therapy. This article on the ACS pathogenesis, diagnosis, serum markers and treatment are summarized below.