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目的研究不同给药方法对重度乙醇中毒患者的催醒效应。方法将75例患者随机分为3组。第一组首剂给予纳络酮0.8mg静脉注射,然后每隔10～30min重复静脉注射纳络酮0.8mg。第二组先给予纳络酮0.8mg静脉注射,然后给予纳络酮1.2mg加入5%葡萄糖氯化钠注射液500ml中持续静脉滴注。第三组一次性给予纳络酮0.8mg静脉注射,不再追加纳络酮用量。结果第一组患者的平均清醒时间及平均肢体正常活动时间明显短于第二组(P<0.05).而第二组患者的平均清醒时间及平均肢体正常活动时间明显短于第三组(P<0.05)。结论重度乙醇中毒患者的治疗中应尽可能选择纳络酮重复给药或持续给药。
Objective To study the awakening effect of different administration methods on patients with severe alcoholism. Methods 75 patients were randomly divided into three groups. The first dose of the first group was given intravenous injection of naloxone 0.8 mg and then intravenous injection of naloxone 0.8 mg every 10-30 minutes. The second group was given intravenous injection of naloxone 0.8mg, and then given intravenous infusion of naloxone 1.2mg added 500ml of 5% glucose and sodium chloride injection. The third group of one-time naloxone 0.8mg intravenous injection, no additional amount of naloxone. Results The average awake time and the mean time to normal limb activity in the first group were significantly shorter than those in the second group (P <0.05), while the average awake time and the average physical activity time in the second group were significantly shorter than those in the third group (P <0.05). Conclusion In the treatment of patients with severe alcoholism, naloxone should be chosen repeatedly or continuously when possible.