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多中心回顾性观察研究评价达托霉素治疗粒细胞减少症患者革兰阳性菌感染的临床疗效。粒细胞缺乏症合并革兰阳性菌感染使用达托霉素治疗患者209例。其中可评价疗效者186例。91%以上为恶性肿瘤患者,其中血液系统恶性肿瘤占73%(135/186)。最常见的感染为导管相关血流感染(43%,79/186)和非导管相关血流感染(36%,67/186)。常见的病原菌为万古霉素耐药粪
A Multicenter Retrospective Observation Study Evaluating the clinical efficacy of daptomycin in the treatment of Gram-positive bacterial infections in patients with neutropenia. 209 patients with agranulocytosis complicated with Gram-positive bacterial infection treated with daptomycin. Which can evaluate the efficacy of 186 cases. More than 91% of patients with malignant tumors, including hematological malignancies accounted for 73% (135/186). The most common infections were catheter-related bloodstream infections (43%, 79 of 186) and non-duct-related bloodstream infections (36%, 67 of 186). The common pathogen is vancomycin-resistant manure