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目的 :探讨病毒性心肌炎患儿免疫功能状态及双黄连的干预作用。方法 :用ELISA及间接免疫荧光法测定了 62例心肌炎患儿血清中柯萨奇B组病毒抗体 (COXB IgM)及T细胞亚群CD+3 、CD+4、CD+8、CD+4/CD+8,并将其随机分成两组 :双黄连组 (3 2例 ,在常规西药基础上加用双黄连 )及常规组 (3 0例 ,除不用双黄连外 ,其余相同 )。结果 :62例心肌炎患儿中 ,3 9例COXB IgM阳性和正常对照有显著性差异 (P <0 0 0 1 ) ;患儿CD+4下降 ,CD+8上升 ,CD+4/CD+8下降 ,用双黄连治疗后 ,患儿临床症状、体征及免疫功能的恢复均优于常规组 (P <0 0 1 )。结论 :病毒性心肌炎患儿存在免疫功能异常及免疫调节功能紊乱 ,注射用双黄连粉剂为治疗小儿病毒性心肌炎的有效药物。
Objective: To investigate the immune function of children with viral myocarditis and the intervention of Shuanghuanglian. Methods: The serum levels of Coxsackie B virus (COXB IgM) and T lymphocyte subsets CD + 3, CD + 4, CD + 8, CD 4 + and CD 4 + were measured by ELISA and indirect immunofluorescence. CD + 8 were randomly divided into two groups: Shuanghuanglian group (32 cases, Shuanghuanglian on the basis of conventional western medicine) and conventional group (30 cases, except for Shuanghuanglian, the rest are the same). Results: Among 62 children with myocarditis, 39 cases had positive COXB IgM and normal controls (P <0.01), CD + 4 decreased, CD + 8 increased, CD + 4 / CD + 8 Decreased, Shuanghuanglian treatment, clinical symptoms, signs and immune function in children were better than the conventional group (P <0.01). Conclusion: Children with viral myocarditis have immunologic dysfunction and immunomodulatory dysfunction. Shuanghuanglian powder for injection is an effective drug for the treatment of viral myocarditis in children.