急性非静脉曲张性上消化道出血(acute nonvarieal upper gastrointedtinal bleeding,ANVUGIB)是临床常见病和多发病,需要得到及时有效的诊治。在内镜治疗前,需要积极扩容及药物治疗,其中,质子泵抑制剂(PPI)有着举足轻重的作用。内镜下治疗能弥补药物治疗的不足,进一步明确出血病灶。内镜下止血失败时,可考虑行血管介入。当患者出血停止后,应积极治疗原发病,防止再出血。 Acute nonvarieal upper gastrointedtinal bleeding (ANVUGIB) is a common clinical disease and frequently-occurring disease, requiring timely and effective diagnosis and treatment. In the endoscopic treatment, the need for active expansion and drug treatment, including proton pump inhibitor (PPI) has a pivotal role. Endoscopic treatment can make up for the lack of drug treatment, to further clarify the bleeding lesions. Endoscopic hemostasis fails, consider vascular intervention. When the patient stops bleeding, should actively treat the primary disease, to prevent further bleeding.