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成纤维细胞生长因子(FGF)在体内分布广泛,对中胚层和神经外胚层来源的组织细胞具有促进分裂增殖和损伤修复的作用。目前已发现的有24种,外源性的aFGF、bFGF、MaFGF是目前应用研究的主要形式,它们通过与组织细胞的表面受体结合,抑制脂质过氧化,拮抗自由基损伤,稳定细胞酶活性,在心血管、肾、神经及肠等器官的机械性或药物性损伤方面发挥保护作用。这提示FGF在组织损伤保护作用方面将有广阔的临床应用前景。
Fibroblast growth factor (FGF) is widely distributed in the body and plays a role in promoting the proliferation, proliferation and repair of mesodermal and neuroectodermal derived tissue cells. So far, 24 kinds of exogenous aFGF, bFGF and MaFGF are the main forms of applied research. They bind lipid peroxidation, inhibit lipid peroxidation, antagonize free radical damage and stabilize cell enzyme by binding with the surface receptors of tissue cells Activity, play a protective role in the mechanical or medicinal damage of cardiovascular, kidney, nerve and intestinal and other organs. This suggests that FGF will have a broad clinical application prospect in tissue damage protection.