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按照药代动力学房室模型,欲维持恒定的血药浓度需要首先给予负荷剂量(LD=Vc·Cd)然后按指数方程补充药物(Q(t)=LD(K_(10)+K_(12)e~(-k21t)+K13e~(-k31t)))。血浆药物流出率概念的提出为在临床麻醉中维持恒定血药浓度找到了更为有效的途径。实际上,它是房室模型理论的修正。微机是将上述理论用于实践的必要手段。微机辅助输液泵的研制成功使静脉麻醉药的血药浓度可以按临床需要随时调节,为麻醉深度的控制提供了条件。
According to the pharmacokinetic compartmental model, to maintain a constant plasma concentration, the first dose (LD = Vc · Cd) and the exponential equation (Q (t) = LD ) e ~ (-k21t) + K13e ~ (-k31t))). The concept of plasma drug efflux rate has found a more effective way to maintain a constant plasma concentration during clinical anesthesia. In fact, it is a modification of the theory of a room model. Microcomputer is the necessary means to apply the above theory to practice. The successful development of computer-assisted infusion pump makes the concentration of intravenous anesthetic blood concentration can be adjusted at any time according to clinical needs, providing the conditions for the depth of anesthesia control.