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目的探讨女性压力性尿失禁(SUI)患者盆底支持结构中MMP-3、胶原蛋白Ⅲ与SUI发生的关系。方法采用免疫组化方法,测定30例压力性尿失禁患者(SUI组)MMP-3,胶原蛋白Ⅲ,并选择同期20例妇科良性病变而行子宫切除术者作为对照(对照组),于手术中取患者阴道前壁,采用免疫组织化学方法观察MMP-3、CollagenⅢ的表达情况。结果SUI组阴道前壁组织中MMP-3表达明显高于对照组(P<0.05),Collagen Ⅲ的表达明显低于对照组(P<0.05)。结论SUI患者阴道前壁组织中胶原代谢活跃、胶原分解增加可能是SUI的发病机制之一。
Objective To investigate the relationship between the expression of MMP-3, collagen Ⅲ and SUI in pelvic floor of female stress urinary incontinence (SUI) patients. Methods 30 cases of stress urinary incontinence (SUI group) and 20 cases of gynecological benign lesions were examined by immunohistochemistry. The patients underwent hysterectomy as control (control group) In patients with vaginal anterior wall, using immunohistochemistry to observe the expression of MMP-3, Collagen Ⅲ. Results The expression of MMP-3 in the anterior vaginal wall of SUI group was significantly higher than that of the control group (P <0.05). The expression of Collagen Ⅲ in SUI group was significantly lower than that in the control group (P <0.05). Conclusions Collagen metabolism is active in the anterior vaginal tissue of SUI patients, and the increased collagen breakdown may be one of the pathogenesis of SUI.