论文部分内容阅读
白细胞介素13(IL-13)是一种多效性Th2细胞因子,与IL-10有部分相似的生物学功能。有报道IL-10能抑制肾小球系膜细胞(MC)表达细胞间粘附分子-1(ICAM-1),亦有报道IL-13抑制体外培养的MC表达一氧化氮合酶mRNA。IL-13对MC表达ICAM-1的影响未见报道,因此本实验拟观察IL-13对体外培养的MC表达ICAM-1的影响。1 材料与方法1.1 实验材料 雄性SD大鼠,体重120-150 g,2-3月
Interleukin-13 (IL-13) is a pleiotropic Th2 cytokine with partial biological function similar to that of IL-10. It has been reported that IL-10 inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) in glomerular mesangial cells (MCs). It has also been reported that IL-13 inhibits the expression of nitric oxide synthase mRNA in MCs cultured in vitro. The effect of IL-13 on the expression of ICAM-1 in MC has not been reported. Therefore, we investigated the effect of IL-13 on the expression of ICAM-1 in MC cultured in vitro. 1 Materials and Methods 1.1 Experimental Materials Male SD rats weighing 120-150 g, 2-3 months