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近年来,不少学者应用丙硫咪唑和甲苯咪唑治疗旋毛虫病,但报道效果不一致。为此,我们比较了丙硫咪唑和甲苯咪唑对实验家兔旋毛虫病的疗效并对治疗前后的抗体反应动态采用ELISA间接法进行了观察,供临床选药参考。 材料与方法 一、实验动物的分组与感染 健康家兔14只,雄性,体重1.5～2.0kg,深灰色。每兔用套有5ml注射器的16号导尿管经口、食道灌入经消化而游离的旋毛虫幼虫1500条。随机分为3组:丙硫咪唑组5只,甲苯咪唑组4只和对照组5只。
In recent years, many scholars use propylthiouracil and mebendazole treatment of trichinosis, but reported inconsistent results. To this end, we compared the efficacy of albendazole and mebendazole on experimental rabbit trichinellosis and observed the antibody response dynamics before and after treatment by ELISA indirect method for clinical drug selection reference. Materials and methods First, the grouping and infection of experimental animals Healthy rabbits 14, male, weighing 1.5 ~ 2.0kg, dark gray. Each rabbit with a set of 5ml syringe on the 16th catheter through the mouth, gastrointestinal infusion of digested free Trichinella larvae 1500. They were randomly divided into 3 groups: 5 in the albendazole group, 4 in the mebendazole group and 5 in the control group.