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目的探讨肝豆状核变性(HLD)患者的心理状况。方法对58例住院HLD患者采用症状自评量表(Scl-90)进行测查,并与43名正常人进行对照。结果HLD患者的焦虑、敌对性、躯体化、抑郁、恐怖因子、阳性项目数与健康对照组比较差别有统计学意义(P<0.001,P<0.01);锥体外系症状为主的HLD患者(脑型)躯体化、焦虑、敌对性、恐怖因子均分高于肝损害为主的HLD患者(肝型,P<0.05)。结论HLD患者有许多心理症状,尤其是脑型HLD患者;在药物驱铜治疗的同时,应重视心理治疗,以提高临床疗效。
Objective To investigate the psychological status of hepatolenticular degeneration (HLD) patients. Methods Fifty-eight inpatients with HLD were evaluated by Scl-90 and compared with 43 healthy controls. Results The number of anxiety, hostility, somatization, depression, terrorist and positive items in HLD patients was significantly lower than that in healthy controls (P <0.001, P <0.01). HLD patients with extrapyramidal symptoms Brain type) somatization, anxiety, hostility, terrorist factors were higher than the liver damage-based HLD patients (liver type, P <0.05). Conclusion There are many psychological symptoms in patients with HLD, especially in patients with brain-type HLD. In the treatment of drug-driven copper, psychotherapy should be emphasized in order to improve clinical efficacy.