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目的通过实验观察碎石清的利尿排石作用。方法采用大鼠水负荷实验代谢笼法观察碎石清的利尿作用;采用乙二醇和氯化铵喂饲法诱发的大鼠肾结石模型,观察碎石清防治结石的作用,检测各组大鼠尿液PH值、尿钙和尿草酸的含量,肾组织钙、草酸和超氧化物歧化酶(SOD)、丙二醛(MDA)水平,以及肾组织中结晶沉积或结石形成的情况。结果碎石清能明显促进大鼠排尿,降低肾组织中草酸和钙离子浓度,升高尿草酸和尿钙量,对大鼠肾结石的形成具有显著的抑制作用,尤以高剂量组明显;碎石清高、低剂量组均能明显升高肾组织SOD活性,高剂量组还能明显减少MDA产生。结论碎石清具有良好的促进排尿和防治结石作用,其机制与抗氧化、减少草酸钙结晶沉积有关。
Objective To observe the effect of lithotripsy on diuretic drainage by experiments. Methods The rat model of renal calculus induced by ethylene glycol and ammonium chloride feeding was used to observe the diuretic effect of sclerotia by rat cataract method. Urinary pH, urinary calcium and urine oxalate, renal tissue calcium, oxalic acid and superoxide dismutase (SOD), malondialdehyde (MDA) levels, and the deposition of crystalline or calcified kidney tissue. The results of the stone can significantly promote urination in rats, reducing the concentration of oxalic acid and calcium in kidney tissue and increasing the concentration of urinary oxalate and urinary calcium, the formation of rat kidney stones significantly inhibited, especially in the high-dose group; Gravel clear, low-dose group were significantly increased SOD activity in renal tissue, high-dose group also significantly reduced MDA production. Conclusion Macadamia can promote urination and prevent stones. Its mechanism is related to anti-oxidation and reducing the crystal deposition of calcium oxalate.