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选取2011年11月~2013年02月呼吸内科住院的76例COPD患者。采用双能X线吸收骨密度仪测量骨密度,进行6分钟步行试验、肺功能检查,动脉血气分析检查。结果 76例COPD急性加重期住院患者中,43例合并OP,骨质疏松检出率为56.6%。COPD合并OP患者6分钟步行距离明显低于单纯COPD组,COPD合并OP组平均Pa O2、FEV1占预计值显著低于单纯COPD组,静脉或口服糖皮质激素的COPD患者并发OP的发生率明显高于吸入糖皮质激素的COPD患者。结论 COPD合并OP患者体力活动能力明显下降,COPD合并OP患者全身应用糖皮质激素时应预防骨折发生。
76 patients with COPD who were hospitalized in respiratory medicine from November 2011 to February 2013 were selected. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. Six-minute walk test, pulmonary function test and arterial blood gas analysis were performed. Results Of the 76 hospitalized patients with acute exacerbation of COPD, 43 were combined with OP, and the detection rate of osteoporosis was 56.6%. COPD patients with OP 6-minute walk distance was significantly lower than the simple COPD group, COPD with OP group average Pa O2, FEV1 accounting for the predicted value was significantly lower than the COPD group, intravenous or oral glucocorticoid COPD patients complicated by the incidence of OP was significantly higher COPD patients who inhaled corticosteroids. Conclusion The physical activity ability of patients with COPD complicated with OP is obviously decreased. The incidence of fractures should be prevented when glucocorticoid is administered systemically in COPD patients with OP.