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目的 比较EP方案 (Vp 16胶囊 ,DDP)与CAP方案 (CTX、ADM与DDP)治疗非小细胞肺癌的疗效。方法 6 0例晚期非小细胞肺癌随机分成两组、各 30例。结果 EP组有效率为38 8%、CAP组为 33 3% ,两组间疗效无显著性差异 (P >0 0 5)。CAP组消化系统毒性作用及脱发反应较EP组严重、造血系统毒性反应相似。结论 两方案可作为老年人非小细胞肺癌一线方案 ,DDP、Vp 16胶囊方案易行、毒副反应小、耐受性好。
Objective To compare the efficacy of EP regimen (Vp 16 capsule, DDP) and CAP regimen (CTX, ADM and DDP) in the treatment of non-small cell lung cancer. Methods Sixty cases of advanced non-small cell lung cancer were randomly divided into two groups, 30 cases each. Results The effective rate was 38.8% in EP group and 33.3% in CAP group. There was no significant difference between the two groups (P> 0.05). The toxicity and the hair loss response of digestive system in CAP group were more serious than those in EP group, and the toxicity of hematopoietic system was similar. Conclusion The two regimens can be used as the first-line plan for elderly patients with non-small cell lung cancer. DDP and Vp 16 capsules are easy to treat with little toxic side effects and good tolerability.