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目的探讨血清CA125变化在肝硬化患者中的临床意义。方法肝硬化住院患者64例,根据Child-pugh积分法分为A级12例,B级23例,C级29例,设正常对照组35例,均为来我院健康体检者,肝硬化患者治疗前后静脉采血,分离血清,应用化学发光法检测血清CA125。结果以血清CA125>35U/L为阳性,64例肝硬化患者中57例阳性,其血清CA125明显高于正常对照组,P<0.05。治疗后与治疗前相比,血清CA125明显下降,P<0.05。Child-pugh分级中,B级较A级及C级较B级血清CA125均显著升高,P<0.05。治疗后A级及B级血清CA125显著下降,P<0.05,C级虽有所下降,但无显著性差异,P>0.05。结论肝硬化患者血清CA125多升高,其水平可作为评判肝功能损害程度、肝硬化预后的指标之一。
Objective To investigate the clinical significance of serum CA125 changes in patients with liver cirrhosis. Methods Sixty-four inpatients with cirrhosis were divided according to Child-pugh score into 12 cases of A grade, 23 cases of B grade, 29 cases of C grade and 35 cases of normal control group, all of whom were from our hospital for physical examination, liver cirrhosis Serum samples were collected before and after treatment, serum was separated and serum CA125 was detected by chemiluminescence method. Results Serum CA125> 35U / L as positive, 64 cases of liver cirrhosis in 57 cases were positive, the serum CA125 was significantly higher than the normal control group, P <0.05. After treatment, compared with before treatment, serum CA125 decreased significantly, P <0.05. Among Child-pugh grading, the serum levels of CA125 in B grade were significantly higher than those in A grade and C grade (P <0.05). After treatment, the level of serum CA125 in Grade A and Grade B decreased significantly (P <0.05). Although Grade C decreased, there was no significant difference (P> 0.05). Conclusion Serum CA125 levels in patients with cirrhosis are elevated, and its level can be used as one of the indicators to judge the degree of liver damage and the prognosis of liver cirrhosis.